As an overview, VS-100 is based the original Skype TX platform, which included both a local SkypeTX client, and a Skype TX controller app, intended primarily for use across a network to control multiple units. Both of these allow you to manage calls (the client app supports just one call, from the local unit). We 'married' our TalkShow UI to the SkypeTX client application window, as you know.
It's different for VS-4000, which is based on the updated Skype TX 4 platform. By design (i.e., Skype TX design, outside our control), there is no 'local client' app. The controller app has gained the ability to control multiple units, each in turn able to be either one or four channel systems. This controller app - which again can be run locally or on another network connected system - provides all call management tools. The NewTek goodness is all hosted in our own independent TalkShow application.
I'm not sure how auto-answer would be expected to work in a multi-channel scenario, but the new controller app, like the older one, does not offer it. Re: the contact lists - the original Skype TX platform has it's own independent contact list, as you know. This was seen, as far as I know, primarily as a security feature in a multi-user environment, but is no longer enforced in Skype TX 4.
Hope this helps clear things up a bit.