Serial port need realtime response and TScript did not have functions related to serial port. So, there is no chance to have that in TScript unless you wrote a serial module to work with TScript. And that means you need C++ and VT SDK.
Yeah, I've got the RS232 stuff down pretty well, I'm just looking for a way to interface it with VT. Ideally, I'd like to be able to create an external control interface for the VT. I know VB2008 pretty well, and I know enough C++ to work with microcontrollers, but the VT docs lost me when it came to triggering TS from C++