Don't misunderstand my intentions, I value the Seuss approach, particularly for a graphic novel kind of look. Very strong and reads well, and yes, I have used it selectively.
I started to just post some examples of what I want to achieve, did a Google search, and found four 'old' threads on the subject, one of which I started and three I participated in all vintage several years ago, and nothing has changed. I went back into some of my simple test files to see if I could now generate the lines I want, and no amount of node tree wrangling was able to create the look??!! This includes a full Lightwave crash every half hour or so, for no particular reason, other than a complex node noodle tree and trying to see the effect of changes in a VPR window. After a couple of hours of no success, I gave up for that day. As stated in this thread and previous ones, I am wanting to create a "hand-drawn" line, which is thinner/lighter on the lit side of all objects and thicker/darker on the 'away' side. It should also be distance/depth variant, lighter/thinner in the distance. I also am trying to couple this with a variable line quality which varies to darker/thicker in the occlusion areas or areas of more tight acute curves. Some of this I can do in Blender!!, but it is a Post Process line, (not on-screen VPR yet) so development gets even slower, making changes, waiting for the render, repeat. Being able to add a Noise channel for somewhat more lively line quality. Overlay this line rendered version in multiply mode, (matte white materials) on top of a color rendered layer which is treated to look more like water color, strengthened with an Occlusion render with slight cross-hatched texture (which I have done successfully and posted in the prior mentioned threads. I recommend anybody to look at the rendering of Hayao Miyazaki (Spirited Away) and Sylvan Chomet (Les Triplettes de Belleville, The Illusionist), Paprika by Satoshi Kon, Your Name, by Makoto Shinkai, and Tekkonkinkreet by Studio 4°C. All excellent examples of lively line in combination with more hand colored textural layers. As an example, here is an illustration by Jason Brubaker from his reMIND book, which I own as inspiration. While I personally find some of his story lines drift theologically for me (Sithrah), his drawings and page layout is totally stunning and excellent. Highly recommend the reMIND book, which you can view online, and also the Sithrah series. He inks up with a Pentel Brush Pen after pencil layout, then builds watercolor flats and fills. Absolutely great stuff and a sincere inspiration for a line rendering style development. If I ever come up with an approximation I will gladly post it.